Further analysis screened 6 prognostic-related MTGs ( ACAD11, ACADSB, BID, PYCR1, SLC25A27, and STAR) and was used to develop a signature. A total of 75 differentially expressed MTGs were analyzed from The Cancer Genome Atlas (TCGA) database, including 46 upregulated and 29 downregulated MTGs. In this study, we aimed to explore the molecular characteristics and prognostic significance of mitochondrial genes (MTGs) related to oxidative stress in clear cell renal cell carcinoma (ccRCC). Its dysfunction can lead to a variety of diseases and promote cancer and metastasis. Mitochondria not only are the main source of ATP synthesis but also regulate cellular redox balance and calcium homeostasis.
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